Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab
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- 作者：Jingtao Luoa ; c ; Yun Hongb ; c ; Yang Luc ; Songbo Qiuc ; Bharat K.R. Chagantyc ; Lun Zhanga ; Xudong Wanga ; Qiang Lia ; Zhen Fanc ; zfan@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACC ; AMPK ; Cetuximab ; EGFR ; HIF-1 ; Warburg effect
- 刊名：Cancer Letters
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：384
- 期：Complete
- 页码：39-49
- 全文大小：4200 K
文摘
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ACC plays a critical role in maintaining cell survival in low glucose conditions.
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A post-cetuximab increase in total ACC contributes to cetuximab resistance.
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ACC rewires cancer metabolism from glycolysis-dependent to lipogenesis-dependent.
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Cetuximab plus ACC inhibitor enhances response of cetuximab-resistant HNSCC cells.