Post-Renal Transplantation Bone Health in Children Evaluated by Means of Quantitative Ultrasound and Densitometry

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• 作者：A.L. Gonzá ; lez-Jorge^a ; S. Enciso^a ; A. Reyes^c ; A.M. Herná ; ndez^a ; L. Ortiz^a ; R. Aldana^a ; F. Velá ; squez-Forero^a ; R. Ambrosi^b ; P. Clark^b ; L. Mé ; ndez^b ; R. Rivas-Ruiz^d ; M. Medeiros^a ; ^e ; ^{medeiro.mara@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Transplantation Proceedings
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：48
• 期：2
• 页码：635-638
• 全文大小：357 K

文摘

Patients with end-stage renal disease develop bone mineral disease, which is not always resolved after a successful renal transplantation; moreover, some of the immunosuppressants used to prevent graft rejection may affect bone health. The aim of this study was to evaluate bone health in post–renal transplantation children with the use of quantitative ultrasound (QUS) and dual-energy X-ray absorptiometry (DXA).

Methods

A descriptive study was performed in children >3 months after renal transplantation and with stable function of graft. Radial QUS and DXA (lumbar spine and total body less head (TBLH) were performed on the same day.

Results

A total of 35 patients were included. Mean age was 13.9 ± 3.9 years. Ten subjects had total bone density score <2 (28.5%), 4 a lumbar spine (L1-L4) Z-score of <2 (11.4%) as well as TBLH <2, and 6 subjects had a radial QUS Z-score of <2 (17.1%), and only 2 of them had concomitant Z-score <2 with the use of DXA. There was a positive non-significant correlation between TBLH and radial QUS Z-scores (Pearson r = 0.317; P = .016) and a positive significant correlation of DXA lumbar spine and radial QUS Z-scores (Pearson r = 0.452; P = .014).

Conclusions

Despite a good correlation between TBLH and QUS Z-scores, there are subjects that can be considered normal by QUS and have osteopenia by TBLH DXA and vice versa; this could be due to the different bone areas evaluated.