Diazepam-palladacycles were prepared by C-H activation of diazepam with palladium salts.
Palladacyclesclass="boldFont">[(DZP)PdCl]2 andclass="boldFont">[(DZP)PdOAc]2 display significant anticonvulsant action.
The antiepileptic potential of the complexes were assessed via the two animal models.
Two promising prototypes of metallodrugs to treat patients with epilepsy were prepared.