α-Terpineol, a monoterpene alcohol, complexed with β-cyclodextrin exerts antihyperalgesic effect in animal model for fibromyalgia aided with docking study
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- 作者：Makson G.B. Oliveiraa ; makson_gbo@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Renan G. Britoa ; guedes_renan@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Priscila L. Santosa ; priscila.laise@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Heitor G. Araú ; jo-Filhoa ; heitorgaf@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jullyana S.S. Quintansa ; jullyanaquintans@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Paula P. Menezesb ; paula.dp.menezes@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mairim R. Serafinib ; maiserafini@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Yasmim M.B.G. Carvalhob ; yasmimgomess@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Juliane C. Silvac ; larbacjuliane@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Jackson R.G.S. Almeidac ; guedesjackson@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Luciana Scottid ; luciana.scotti@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Marcus T. Scottid ; mtscotti@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Saravanan Shanmugamb ; saranflora04@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Parimelazhagan Thangaraje ; drparimel@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Adriano A.S. Araú ; job ; adriasa2001@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Lucindo J. Quintans-Jú ; niora ; lucindojr@gmail.com" class="auth_mail" title="E-mail the corresponding author ; lucindo@pq.cnpq.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：α-Terpineol ; β-Cyclodextrin ; Fibromyalgia ; Chronic pain ; Pain ; Opioid
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 July 2016
- 年：2016
- 卷：254
- 期：Complete
- 页码：54-62
- 全文大小：1414 K
文摘
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β-Cyclodextrin (βCD) improves anti-hyperalgesic effect of α-terpineol (αTPN).
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αTPN-βCD producied a longer lasting analgesic profile when compared to αTPN.
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Docking study suggested that αTPN-βCD seems to implies the opioid and serotoninergic receptors.