Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells
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- 作者：Sara E. Perry ; Philip Robinson ; Alan Melcher ; Philip Quirke ; Hans-Jö ; rg Bü ; hring ; Graham P. Cook ; G. Eric Blair
- 关键词：CUB domain ; CUB domain containing protein 1 ; Epithelial cell adhesion molecule ; Carcinoembryonic antigen ; Colorectal cancer
- 刊名：FEBS Letters
- 出版年：2007
- 出版时间：20 March 2007
- 年：2007
- 卷：581
- 期：6
- 页码：1137-1142
- 全文大小：421 K
文摘
Expression of CUB domain containing protein 1 (CDCP1) is upregulated in carcinoma cells. We quantitated CDCP1 gene expression in matched normal colon and tumour tissue and compared the level of expression to other genes upregulated in colorectal tumourigenesis. Furthermore, we show that the CDCP1 gene generates two transcripts which are co-expressed in normal and matched tumour tissue as well as in the majority of cell lines analysed. However, intracellular localisation studies revealed that only one of these transcripts encodes a protein that is localised to the cell surface.