Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterolabsorption and LDL cholesterol

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• 作者：Curtis A Spilburg ; Anne C Goldberg ; Janet B McGill ; William F Stenson ; Susan B Racette ; Joyce Bateman ; Timothy B McPherson ; Richard E Ostlund ; Jr
• 关键词：dietary supplements ; coding ; bladder cancer
• 刊名：Journal of the American Dietetic Association
• 出版年：2003
• 出版时间：May 2003
• 年：2003
• 卷：103
• 期：5
• 页码：577-581
• 全文大小：100 K

文摘

Objective The objective of this work was to show that fat-free, lecithin-formulated soy stanols lower cholesterol absorption and serum LDL cholesterol. Design Reduction in cholesterol absorption was measured in paired single-meal tests with or without formulated soy stanols (acute test), and changes in serum lipids were investigated in a 10-week, randomized, double-blind parallel trial in which formulated stanols or lecithin vehicle were given three times daily for the last 4 weeks (chronic test). Subjects/setting Forty-five normal or mildly hypercholesterolemic subjects were recruited for both studies. The 21 subjects (16 female, 5 male; mean age 32.5 years) in the absorption studies had the following mean lipid values: LDL cholesterol, 2.79 mmol/L and total cholesterol, 4.73 mmol/L. For the lipid reduction, 24 subjects (16 female, 8 male; mean age 50.6 years) were enrolled with mean LDL cholesterol and total cholesterol of 3.72 mmol/L and 5.66 mmol/L, respectively. Intervention Reduction in cholesterol absorption was measured using a lemonade beverage or egg whites that contained 625 mg stanols. Throughout the chronic study, subjects followed the American Heart Association Step I diet. During the 4-week treatment phase, subjects consumed daily a lemonade-flavored beverage containing either placebo or formulated soy stanols (1.9 g). Main outcome measures Inhibition of cholesterol absorption was determined from the difference in plasma deuterated cholesterol enrichment after a test meal containing stanol-lecithin and one with lecithin vehicle only. In the chronic study, the primary endpoints were changes in LDL and total cholesterol. Statistical analyses performed Paired or unpaired t tests were used to determine statistical significance. Results Stanol-lecithin reduced cholesterol absorption by 32.1 % (P=.0045, n=10) and by 38.2 % (P=.0022, n=11) when delivered in a lemonade-flavored beverage and in egg whites, respectively. Reduction in cholesterol absorption was strongly related to the initial level of absorbed cholesterol tracer in serum (rb>sb>=−0.739). Stanol-lecithin given in a beverage reduced total serum cholesterol by 10.1 % (P=.0019, n=24) and LDL cholesterol by 14.3 % (P=.0016, n=24). Applications/conclusions Powdered soy stanol-lecithin lowers cholesterol absorption and LDL cholesterol when consumed in fat-free foods. J Am Diet Assoc. 2003;103:577-581.