Bronchopulmonary infection-colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study

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• 作者：Juan de Dios Caballero^a ; ^b ; Rosa del Campo^a ; ^b ; Ana Royuela^c ; Amparo Solé ; ^d ; Luis Má ; iz^e ; Casilda Olveira^f ; Esther Quintana-Gallego^g ; ^h ; Javier de Gracia^h ; ⁱ ; Marta Cobo^a ; Elia Gó ; mez G. de la Pedrosa^a ; ^b ; Antonio Oliver^b ; ^j ; Rafael Cantó ; n^a ; ^b ; ^{rafael.canton@salud.madrid.org" class="auth_mail" title="E-mail the corresponding author} ; ; the GEIFQ (Grupo Españ ; ol para el Estudio de la Colonizació ; n/Infecció ; n Broncopulmonar en Fibrosis Quí ; stica) The GEIFQ Study Group (Grupo Españ ; ol para el Estudio de la Colonizació ; n/Infecció ; n Broncopulmonar en Fibrosis Quí ; stica)
• 关键词：Cystic fibrosis ; Pulmonary infection&ndash ; colonization ; Respiratory pathogens ; P. aeruginosa
• 刊名：Journal of Cystic Fibrosis
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：15
• 期：3
• 页码：357-365
• 全文大小：479 K

文摘

Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented.

Methods

24 CF-Units for adult (n = 12) and pediatric (n = 12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed.

Results

341 patients [mean (SD) age 21 (11) years, 180 ≥ 18 years, mean (SD) FEV₁ = 68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV₁ (p < 0.001 and p = 0.003, respectively).

Conclusions

The representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically characterized will serve as a reference for future CF studies in Spain.