(5R)-5-Alkyl-5,6-dihydroindolizines via stereospecific domino hydroformylation/cyclodehydration of (3R)-3-(pyrrol-1-yl)alk-1-enes

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• 作者：Settambolo ; Roberta ; Guazzelli ; Giuditta ; Mandoli ; Alessandro ; Lazzaroni ; Raffaello
• 刊名：Tetrahedron: Asymmetry
• 出版年：2004
• 出版时间：June 21, 2004
• 年：2004
• 卷：15
• 期：12
• 页码：1821-1823
• 全文大小：250 K

文摘

(5R)-5-Alkyl-5,6-dihydroindolizines 3a–c having the same high enantiomeric excess (>92 % ) as the corresponding starting olefins (3R)-3-(pyrrol-1-yl)alk-1-enes 1a–c were obtained via a highly regioselective and stereospecific domino hydroformylation/cyclodehydration reaction sequence. The reasons for this configurational stability were also analyzed in the light of the general accepted rhodium catalyzed hydroformylation mechanism.