Epigenetic disruption of miR-130a promotes prostate cancer by targeting SEC23B and DEPDC1

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• 作者：Joã ; o Ramalho-Carvalho^a ; ^b ; Joã ; o Barbosa Martins^a ; Lina Cekaite^c ; ^d ; Anita Sveen^c ; ^d ; Jorge Torres-Ferreira^a ; Inê ; s Graç ; a^a ; ^e ; Pedro Costa-Pinheiro^a ; Ina Andrassy Eilertsen^c ; Luí ; s Antunes^f ; Jorge Oliveira^g ; Ragnhild A. Lothe^c ; ^d ; Rui Henrique^a ; ^h ; ⁱ ; Carmen Jeró ; nimo^a ; ⁱ ; ^{carmenjeronimo@ipoporto.min-saude.pt} ; ^{cljeronimo@icbas.up.pt}
• 关键词：miR's epigenetic regulation ; miR-130a ; miRNA ; Prostate cancer ; SEC23B ; DEPDC1
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：150-159
• 全文大小：2676 K
• 卷排序：385

文摘

The global microRNA downregulation observed in Prostate Cancer is a combined result of epigenetic and microRNA biogenesis machinery's alterations. miR-130a is a new epigenetically regulated, tumour-suppressor miRNA critical for reversion of Prostate cancer cells malignant phenotype. SEC23B and DEPDC1 are specific targets of miR-130a and contribute to the prostatic carcinogenesis. miR-130a is a specific prostate cancer biomarker.