A novel alkaloid, evodiamine causes nuclear localization of cytochrome-c and induces apoptosis independent of p53 in human lung cancer cells
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- 作者：Vijay Mohana ; Rajesh Agarwalc ; Rana P. Singha ; b ; ranaps@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; rana_singh@mail.jnu.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Evodiamine ; Lung cancer ; p53 ; Apoptosis ; Pifithrin-α ; Cytochrome-c
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：477
- 期：4
- 页码：1065-1071
- 全文大小：1413 K
文摘
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Evodiamine, a novel plant alkaloid, relatively selectively inhibited growth and survival of human lung cancer cells.
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Increased cancer cell apoptosis involving mitochondrial membrane depolarization.
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Increased the cytochrome-c release from mitochondria into the cytosol as well as nucleus.
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DR5 and caspase-8 extrinsic pathway was also activated in p53-independent manner.
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Thus evodiamine could be a potential anticancer agent against lung cancer.