Enhanced LTP in aged rats: Detrimental or compensatory?

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• 作者：Jú ; lia Pinho^a ; ^b ; ^{julia13pinho@gmail.com} ; Ruben Vale^a ; ^b ; ¹ ; ^{rubenduque@gmail.com} ; Vâ ; nia L. Batalha^b ; ^{vanialnbatalha@gmail.com} ; Ana Rita Costenla^a ; ^b ; ^{arcosntenla@gmail.com} ; Raquel Dias^a ; ^b ; ^{r.alice@gmail.com} ; Diogo Rombo^a ; ^b ; ^{d.rombo@gmail.com} ; Ana M. Sebastiã ; o^a ; ^b ; ^{anaseb@medicina.ulisboa.pt} ; Alexandre de Mendon&ccedil ; a^b ; ^{mendoca@medicina.ulisboa.pt} ; Maria José ; Dió ; genes^a ; ^b ; ^{diogenes@medicina.ulisboa.pt}
• 关键词：Aging ; Long-term potentiation ; Spatial learning ; Hippocampus ; Watermaze
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：114
• 期：Complete
• 页码：12-19
• 全文大小：975 K
• 卷排序：114

文摘

LTP recorded in hippocampal slices from aged rats is larger than in young rats. Memantine decreases hippocampal LTP in aged animals and leads to learning deficits. Larger LTP observed in aged animals is a compensatory phenomenon.