TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation
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- 作者：Dafni-Eleftheria Pefani1 ; Daniela Pankova1 ; Aswin G. Abraham1 ; Anna M. Grawenda1 ; Nikola Vlahov1 ; Simon Scrace1 ; Eric O&rsquo ; Neill1 ; eric.oneill@oncology.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：7 July 2016
- 年：2016
- 卷：63
- 期：1
- 页码：156-166
- 全文大小：3449 K
文摘
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Lung and breast tumors lacking RASSF1A display aberrant TGF-β signaling
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TGF-β stimulates RASSF1A recruitment to TGF-βRI and degradation via the ITCH E3 ligase
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YAP1-dependent nuclear localization of SMAD2 requires loss of RASSF1A
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RASSF1A restricts TGF-β−mediated transcription and invasion