Aqueous microwave-assisted DMAP catalyzed synthesis of β-phosphonomalonates and 2-amino-4H-chromen-4-ylphosphonates via a domino Knoevenagel-phospha-Michael reaction

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• 作者：Parteek Kour^a ; Anil Kumar^a ; ^{anilsharmachemistry@gmail.com} ; Vijai K. Rai^b
• 关键词：DMAP ; Microwave ; Domino reaction ; β-Phosphonomalonates ; 2-Amino-4H-chromen-4-ylphosphonates ; Aqueous condition
• 刊名：Comptes Rendus Chimie
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：20
• 期：2
• 页码：140-145
• 全文大小：853 K
• 卷排序：20

文摘

An aqueous microwave (mw)-assisted DMAP catalyzed one-pot highly efficient route to synthesize β-phosphonomalonates and 2-amino-4H-chromen-4-yl phosphonates has been demonstrated via the domino Knoevenagel-phospha-Michael reaction of aryl aldehyde/salicylaldehyde, malononitrile/ethyl cyanoacetate and alkyl phosphite ester. Optimization of reaction conditions were performed by using conventional and microwave synthetic approaches. This conversion proceeded smoothly to deliver the desired product in good to excellent yields (75–95%) in a short reaction time (10–12 min). The present methodology is very simple, environmentally benign, high yielding and has very well demonstrated the synergistic effect of water and microwaves.