Highly enantioselective Michael-aldol-dehydration reaction for the synthesis of chiral 3,5-diaryl-cyclohexenones catalyzed by primary amine

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• 作者：Li Tang ; Yuan Luo ; Jing-Wen Xue ; Yan-Hong He ; ^{heyh@swu.edu.cn} ; Zhi Guan ; ^{guanzhi@swu.edu.cn}
• 关键词：Organocatalysis ; Domino reaction ; 3 ; 5-diaryl-cyclohexenones ; Enantioselective synthesis
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：23 February 2017
• 年：2017
• 卷：73
• 期：8
• 页码：1114-1119
• 全文大小：393 K
• 卷排序：73

文摘

A simple organocatalytic Michael-aldol-dehydration domino approach to chiral 3,5-diaryl-cyclohexenones from acetone and α,β-unsaturated ketones was developed for the first time using a simple chiral primary amine as a catalyst. Moderate to good yields (up to 85%) and excellent enantioselectivities (88–98% ee) were obtained.