Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue
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- 作者：Kosuke Okada1 ; Katherine B. LeClair1 ; Yongzhao Zhang1 ; 4 ; Yingxia Li1 ; Cafer Ozdemir1 ; Tibor I. Krisko1 ; Susan J. Hagen2 ; Rebecca A. Betensky3 ; Alexander S. Banks1 ; David E. Cohen1 ; dcohen@partners.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Energy expenditure ; Fatty acyl-CoA ; Acyl-CoA thioesterase ; Mitochondria ; Obesity
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：5
- 期：5
- 页码：340-351
- 全文大小：1426 K
文摘
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Them1 is a fatty acyl-CoA thioesterase that is highly expressed in brown adipose tissue.
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Them1 expression is strongly upregulated by cold ambient temperatures.
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Mice lacking Them1 exhibit increased cold thermogenesis.
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Them1 limits the mitochondrial oxidation of lipid-droplet derived fatty acids.