Galectin-3 binds highly galactosylated IgG1 and is crucial for the IgG1 complex mediated inhibition of C5aReceptor induced immune responses
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- 作者：Kerstin A. Heyla ; Christian M. Karstenb ; 1 ; Hortense Slevogta ; 1 ; hortense.slevogt@med.uni-jena.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Galectin-3 ; IgG1 immune complexes ; Fc FcγRIIB-Dectin-1 receptor complex ; Neutrophil chemotaxis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：7 October 2016
- 年：2016
- 卷：479
- 期：1
- 页码：86-90
- 全文大小：671 K
文摘
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Higal-IgG1 ICs inhibits C5a-mediated inflammation via FcγRIIB-Dectin-1 complexes.
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Galectin-3 binds murine IgG1, depending on Fc-galactosylation.
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Regulation of C5a-induced neutrophil chemotaxis via IgG1-IC depends on Galectin-3.
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An interaction of Galectin-3 with FcγRIIB-Dectin-1 receptor complexes is proposed.