Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice
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- 作者：Ujala Ranaa ; b ; d ; 1 ; Zhong Liua ; b ; d ; 1 ; Suresh N. Kumarb ; d ; Baofeng Zhaoa ; b ; d ; Wenquan Hua ; b ; d ; Michelle Bordasc ; d ; Stephanie Cossettec ; d ; Sara Szabob ; d ; Jamie Foecklerf ; h ; Hartmut Weilerf ; h ; Magdalena Chrzanowska-Wodnickah ; Mary L. Holtze ; Ravindra P. Misrae ; Valerie Salatob ; d ; Paula E. Northb ; d ; Ramani Ramchandranc ; d ; g ; rramchan@mcw.edu" class="auth_mail" title="E-mail the corresponding author ; Qing Robert Miaoa ; b ; d ; qmiao@mcw.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：410
- 期：2
- 页码：190-201
- 全文大小：12965 K
文摘
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We demonstrated the role of NgBR in regulating blood vessel formation in mouse.
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NgBR knockout in endothelial cells (ecKO) impairs cerebral blood vessel assembly.
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NgBR is a novel factor regulating the expression of CCM1 and CCM2 genes.
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NgBR levels in endothelial cells are decreased in CCM patient tissue sections.
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NgBR loss in endothelial cells is a risk factor for cerebral vascular anomalies.