Early changes in adipokines from overweight to obesity in children and adolescents

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• 作者：Rafael Machado Mantovani^a ; Natá ; lia Pessoa Rocha^b ; Daniel Massote Magalhã ; es^b ; Izabela Guimarã ; es Barbosa^b ; Antô ; nio Lú ; cio Teixeira^b ; ^c ; Ana Cristina Simõ ; es e Silva^a ; ^b ; ^{acssilva@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Leptin ; Adiponectin ; Resistin ; Metabolic markers ; Soluble tumor necrosis factor receptor
• 刊名：Jornal de Pediatria
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：92
• 期：6
• 页码：624-630
• 全文大小：734 K

文摘

Childhood obesity has been associated with metabolic syndrome and cardiovascular diseases. This study aimed to compare plasma levels of traditional metabolic markers, adipokines and soluble tumor necrosis factor receptor type 1 (sTNFR1) in overweight, obese and lean children. We also assessed the relationships of these molecules with classical metabolic risk factors.

Methods

This study included 104 children and adolescents, which were grouped as: lean (n = 24), overweight (n = 30), and obese subjects (n = 50). They were subjected to anthropometrical, clinical and laboratorial measurements. All measurements were compared between groups. Correlation analyses were also performed to evaluate the association between clinical data, traditional metabolic markers, adipokines and sTNFR1.

Results

Fasting glucose, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), LDL-cholesterol and triglycerides were comparable in lean, overweight and obese subjects. Plasma levels of sTNFR1 were similar in lean and overweight subjects, but significantly increased in obese group. Leptin, adiponectin and resistin levels did not differ when overweight were compared to obese subjects. However, all adipokines differed significantly when lean subjects were compared to overweight and obese individuals. Plasma levels of adiponectin were negatively correlated with body mass index (BMI), whereas leptin, resistin and sTNFR1 concentrations positively correlated with BMI.

Conclusion

Our results showed significant differences in circulating levels of the evaluated markers when lean, overweight and obese individuals were compared, suggesting that these biomarkers may change from lean to overweight and from overweight to obesity.