sm“FISH”ing for Hedgehog

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• 作者：Michael L. Drummond¹ ; Scott X. Atwood¹ ; ² ; ^{satwood@uci.edu}
• 刊名：Journal of Investigative Dermatology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：1
• 页码：13-15
• 全文大小：404 K
• 卷排序：137

文摘

Patched (Ptch) receptors are critical negative regulators of Hedgehog signaling, where Ptch1 loss causes basal cell carcinoma and Ptch1;Ptch2 loss disrupts skin and hair follicle development. Adolphe et al. use single molecule fluorescent in situ hybridization to show quantitatively that Ptch receptors create a Hedgehog signaling gradient that may specify hair follicle development.