Dopamine D1 signaling involvement in the effects of the phosphodiesterase 10A inhibitor, PDM-042 on cognitive function and extrapyramidal side effect in rats
详细信息 查看全文
- 作者：Keita Arakawaa ; Kazunari Nakaob ; Shunsuke Maeharaa ; shunsuke.maehara@mochida.co.jp" class="auth_mail" title="E-mail the corresponding author ; maehrasn@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Phosphodiesterase 10A (PDE10A) ; Novel object recognition ; Catalepsy ; Dopamine ; Schizophrenia
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：204-209
- 全文大小：623 K
文摘
- •
The novel PDE10A inhibitor, PDM-042, enhanced object recognition memory in rats.
- •
A dopamine D1 antagonist, SCH23390, blocked the pro-cognitive effect of PDM-042.
- •
SCH23390 potentiated the cataleptic effect of PDM-042.
- •
Dopamine D1 signaling may be involved in the pharmacological effects of PDM-042.