Widely used pharmaceuticals present in the environment revealed as in vitro antagonists for human estrogen and androgen receptors
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- 作者：Martin Ezechiá ; &scaron ; a ; b ; Jana Janochová ; a ; Alena Filipová ; a ; Zdena Křesinová ; a ; b ; Tomá ; &scaron ; Cajthamla ; b ; cajthaml@biomed.cas.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Endocrine disruptor ; Anti-estrogenic ; Anti-androgenic ; Anti-inflammatory pharmaceuticals ; CXCL12 ; Recombinant yeast assay
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：152
- 期：Complete
- 页码：284-291
- 全文大小：586 K
文摘
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CXCL12-T47D and YES assays showed endocrine disrupting potency of pharmaceuticals.
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Anti-inflammatory drugs exhibited anti-estrogenic and anti-androgenic properties.
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Dose dependency of this endocrine disrupting effect has been proved.
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The results can explain some mechanisms of adverse effects on humans and wildlife.