Probabilistic 3D MRI atlas of the human cerebellar dentate/interposed nuclei

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• 作者：A. Dimitrova ; D. Zeljko ; F. Schwarze ; M. Maschke ; M. Gerwig ; M. Frings ; A. Beck ; V. Aurich ; M. Forsting and D. Timmann
• 关键词：Cerebellar nuclei ; Cerebellum ; Atlas ; Human ; MRI
• 刊名：NeuroImage
• 出版年：2006
• 出版时间：March 2006
• 年：2006
• 卷：30
• 期：1
• 页码：12-25
• 全文大小：1083 K

文摘

In a previous study, a three-dimensional (3D) MRI atlas of the human cerebellar nuclei was introduced based on findings in one healthy human subject [Dimitrova, A., Weber, J., Redies, C., Kindsvater, K., Maschke, M., Kolb, F.P., Forsting, M., Diener, H.C., Timmann, D., 2002. MRI atlas of the human cerebellar nuclei. NeuroImage 17, 240–255]. The present MRI investigation was designed to study variability of the anatomy of the dentate/interposed nuclei in a larger group of healthy subjects. Similar to our previous study, iron-induced susceptibility artifacts were used to visualize the cerebellar nuclei as hypointensities on MR images. Data of 63 healthy subjects (27 female, 36 male; mean age 45.3 ± 13.4 years, age range 22–71 years) were included. A 3D axial volume of the cerebellum was acquired using a T2*-weighted FLASH sequence on a Siemens Sonata 1.5 T MR scanner. Each volume was registered, resampled to 1.00 × 1.00 × 1.00 mm³ voxel size and spatially normalized into a standard proportional stereotaxic space using SPM99. Dentate/interposed nuclei were traced on axial images and saved as regions of interest using MRIcro-software by two independent examiners. A probabilistic 3D MRI atlas of the cerebellar dentate/interposed nuclei is presented based on findings in all subjects.