- 作者：Lisa Zipparo ; Thomas J. Whitford ; Marie Antoinette Redoblado Hodge ; Sara Lucas ; Tom F.D. Farrow ; John Brennan ; Lavier Gomes ; Leanne M. Williams ; Anthony W.F. Harris
- 关键词：First-episode schizophrenia ; Longitudinal ; Neuroanatomy ; Neuropsychology
- 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 出版年：2008
- 出版时间：15 February 2008
- 年：2008
- 卷：32
- 期：2
- 页码：531-538
- 全文大小：318 K
Methods
Fifty-two patients with FES underwent neuropsychological testing and a structural magnetic resonance imaging (sMRI) scan within three months of their first presentation to mental health services with psychotic symptoms (time1). Patients' cognitive performance was evaluated via an extensive neuropsychological test battery, which assessed 9 cognitive domains. Of the 52 patients at time1, 32 returned 2–3 years later (time2) for follow-up neuropsychological testing, and 20 of these also underwent follow-up sMRI. MR images were preprocessed in SPM99. Grey matter volumes of patients' whole-brain, frontal lobes and temporal lobes were calculated by convolving the preprocessed images with manually-drawn binary masks.
Results
Patients exhibited longitudinal improvements in full-scale IQ, performance IQ and visual memory. In contrast, concurrent reductions in grey matter were observed for the whole-brain (3 % reduction) and the frontal lobe (3.65 % reduction). Furthermore, the extent of patients' whole-brain and frontal-lobe grey matter changes were positively correlated with longitudinal changes in verbal learning and memory.
Discussion
The results of this study suggest that while the early stages of schizophrenia are associated with a mild improvement in patients' overall cognitive functioning, they are also associated with progressive grey matter atrophy.