Aldo-keto reductase 1B10 promotes development of cisplatin resistance in gastrointestinal cancer cells through down-regulating peroxisome proliferator-activated receptor-γ-dependent mechanism
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- 作者：Toshiyuki Matsunagaa ; matsunagat@gifu-pu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Ayaka Suzukia ; Chihiro Kezukaa ; Naoko Okumuraa ; Kazuhiro Iguchib ; Ikuo Inouec ; Midori Sodad ; Satoshi Endoa ; Ossama El-Kabbanie ; Akira Haraf ; Akira Ikaria
- 关键词：Aldo-keto reductase 1B10 ; Cisplatin ; Gastrointestinal cancer cells ; Chemoresistance ; Peroxisome proliferator-activated receptor-γ
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：256
- 期：Complete
- 页码：142-153
- 全文大小：990 K
文摘
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AKR1B10 is up-regulated with CDDP resistance in gastrointestinal cancer cells.
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PPARγ is down-regulated in the CDDP-resistant cells.
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AKR1B10 detoxifies reactive aldehydes and suppresses PPARγ expression.
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Treatment with AKR1B10 inhibitor and PPARγ ligand overcomes the CDDP resistance.