Upstream regulators and downstream effectors of NF-κB in Alzheimer's disease
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- 作者：Zhe-Min Shia ; Ya-Wei Hana ; Xiao-Hui Hana ; Kun Zhanga ; Ya-Nan Changa ; Zhi-Mei Hua ; Hai-Xia Qib ; Chen Tinga ; Zhang Zhena ; Wei Honga ; hong_wei889@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer's disease ; LOAD ; late-onset Alzheimer's disease ; NF-κB ; nuclear factor kappa B ; IKK ; IκB kinase ; TNFα ; tumor necrosis factor α ; IL-1β ; interleukin 1β ; APP ; amyloid precursor protein ; BACE1 ; β-site APP cleaving enzyme1 ; ROS ; reactive oxygen species ; PI3-K ; phosphatidyl inositol 3-kinase ; MAPK ; mitogen-activated protein kinase ; ERK ; extracellular signal-regulated kinase ; JNK ; c-Jun N-terminal kinase ; MnSOD ; manganese superoxide dismutase ; TGF-β ; transforming growth factor-β ; AGE ; adv
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：366
- 期：Complete
- 页码：127-134
- 全文大小：625 K
文摘
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Upstream regulators Aβ, ROS, inflammation cytokines, non-coding RNAs activate NF-κB in AD
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PI3K/AKT, MAPK and AGE/RAGE/GSK-3 pathways involve in AD by activating NF-κB
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Downstream effectors of NF-κB inferred with Aβ, ROS, inflammation cytokines, non-coding RNAs accelerate AD