Synthesis of dual responsive carbohydrate polymer based IPN microbeads for controlled release of anti-HIV drug
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- 作者：S. Eswaramma ; K.S.V. Krishna Rao ; ksvkr@yogivemanauniversity.ac.in" class="auth_mail" title="E-mail the corresponding author ; drksvkrishna@yahoo.com" class="auth_mail" title="E-mail the corresponding author (Assistant Professor)
- 关键词：Sodium alginate ; Guar gum ; N-Vinylcaprolactam ; Zidovudine ; Anti-HIV drug release ; Dual-responsive
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：20 January 2017
- 年：2017
- 卷：156
- 期：Complete
- 页码：125-134
- 全文大小：2462 K
文摘
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Grafting of poly(N-vinyl caprolactam) on to guar gum back bone.
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Dual responsive IPN hydrogel microbeads were developed from sodium alginate and graft copolymer.
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In vitro release studies were performed for anti-HIV model drug, Zidovudine.
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pH and temperature are key factors during the swelling and drug release studies.