Progranulin protects against endotoxin-induced acute kidney injury by downregulating renal cell death and inflammatory responses in mice
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- 作者：Xiaoying Xua ; Linfeng Goua ; Meng Zhoub ; Fusheng Yangc ; Yihan Zhaoa ; Tingting Fenga ; Peikun Shia ; Armin Ghavamiana ; Weiming Zhaoa ; Yuan Yud ; Yi Luc ; Fan Yib ; Guangyi Liue ; guangyi.liu3@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Wei Tanga ; weitang@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Progranulin ; Endotoxemia ; Acute kidney injury ; Apoptosis ; Inflammation
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：409-419
- 全文大小：4237 K
文摘
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Progranulin (PGRN) expression is elevated in the kidney of an endotoxin-induced AKI mouse model.
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PGRN deficiency exacerbates renal injury of mice after LPS infusion.
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Recombinant PGRN pretreatment protects against endotoxin-induced AKI in wild-type (WT) and PGRN-deficient mice.
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PGRN ameliorates renal cell death and inflammatory responses in LPS-infused mice.