Chrysin cocrystals: Characterization and evaluation

详细信息    查看全文

• 作者：Renu Chadha ; ^{renukchadha@rediffmail.com} ; Yashika Bhalla ; Avdesh Nandan ; Kunal Chadha ; Maninder Karan
• 关键词：Chrysin ; Cocrystals ; DSC ; FTIR ; PXRD ; Antioxidant ; Anti-inflammatory ; Antihaemolytic ; Pharmacokinetics
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：134
• 期：Complete
• 页码：361-371
• 全文大小：2893 K
• 卷排序：134

文摘

Preparation of the cocrystals of chrysin molecule with cytosine and thiamine hydrochloride. Characterization of the cocrystals by DSC, PXRD, FT-IR and SSNMR. Cocrystallization of chrysin improves its solubility, dissolution profile and bioavailability parameters. Improved antioxidant, antihaemolytic and anti-inflammatory activities are observed in the cocrystals of chrysin.