A Pluripotency Platform for Prdm14

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• 作者：Adam Burton² ; ^{adam.burton@helmholtz-muenchen.de" class="auth_mail" title="E-mail the corresponding author} ; Maria-Elena Torres-Padilla¹ ; ²
• 刊名：Developmental Cell
• 出版年：2016
• 出版时间：11 July 2016
• 年：2016
• 卷：38
• 期：1
• 页码：3-5
• 全文大小：480 K

文摘

The tripartite network of Prdm14, Blimp1, and AP2γ is essential for the important process of germ cell specification, but their precise molecular mechanisms of action remain lacking. Tu and colleagues (2016) report in Nature that the transcriptional co-repressor CBFA2T2 is an essential interactor protein regulating PRDM14 function, shedding light into the mechanisms directing germline formation and pluripotency.