Protein aggregation and ER stress
详细信息 查看全文
- 作者：Navit Ogen-Shterna ; b ; Tamuz Ben Davida ; b ; Gerardo Z. Lederkremera ; b ; gerardo@post.tau.ac.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aβ ; (β-amyloid peptide) ; AD ; (Alzheimer's disease) ; ALS ; (Amyotrophic Lateral Sclerosis) ; APP ; (amyloid precursor protein) ; ATF6 ; (activating transcription factor 6) ; CNX ; (calnexin) ; eIF2α ; (Eukaryotic Initiation Factor 2 α ; ER ; (endoplasmic reticulum) ; ERAD ; (ER-associated degradation) ; ERQC ; (ER-derived quality control compartment) ; HD ; (Huntington's disease) ; Htt ; (Huntingtin) ; IRE1 ; (inositol requiring 1) ; MAM ; (ER-mitochondria associated membranes) ; NDs ; (neurodegenerative diseases) ; PD ; (
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：1648
- 期：part_PB
- 页码：658-666
- 全文大小：927 K
文摘
- •
Protein aggregation is a main feature of most of the neurodegenerative diseases.
- •
10">The toxic species are oligomeric forms and not the final amyloid aggregates.
- •
15">ER stress develops, is a major cause of disease and could be a therapeutic target.