Contribution of the oligodendrocyte lineage to CNS repair and neurodegenerative pathologies
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- 作者：Reshmi Tognatta ; Robert H. Miller ; Rhm3@gwu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oligodendrocytes ; Myelination ; Neurodegeneration ; Multiple sclerosis ; ALS ; Alzheimer's disease
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：110
- 期：part_PB
- 页码：539-547
- 全文大小：660 K
文摘
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Remyelination failure after a demyelinating episode is a key feature of MS.
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Parenchymal and SVZ-derived OPCs form a remyelinating cell niche in the adult CNS.
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Oligodendroglia have a myelin-independent role in neuronal survival and protection.
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Oligodendrocyte-targeted therapeutic strategies to treat neurodegenerative diseases.