Distribution and antibacterial susceptibility of macrolide resistance genotypes in Streptococcus pneumoniae: PROTEKT Year 5 (2003–2004)

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• 作者：David J. Farrell ; Catherine Couturier ; Waleria Hryniewicz
• 关键词：Macrolide resistance ; Genotyping ; Streptococcus pneumoniae ; Surveillance ; Community-acquired pneumonia ; PROTEKT
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：31
• 期：3
• 页码：245-249
• 全文大小：151 K

文摘

The distribution and antibacterial susceptibility of macrolide resistance genotypes among 7083 Streptococcus pneumoniae isolates collected worldwide during 2003–2004 from patients with community-acquired respiratory tract infections, including patients within 48 h of admission to hospital, were analysed. The overall rate of erythromycin resistance was 37.2 % (intercountry range <10 % to >50 % ). The most common resistance mechanism globally was erm(B) (55.0 % of erythromycin-resistant S. pneumoniae (ERSP)), followed by mef(A) (30.6 % ) and erm(B) + mef(A) (12.0 % ). Genotype distribution varied by age group (P < 0.0001); erm(B) + mef(A) was more prevalent (21.8 % of isolates) among patients 0–2 years of age than among other age groups (P < 0.001). The prevalence of tetracycline resistance among mef(A) isolates varied between different countries. Of the erm(B) + mef(A) strains, 43.5 % were resistant to amoxicillin/clavulanic acid. Most ERSP isolates were susceptible to levofloxacin (98.3 % ) and telithromycin (99.4 % ).