Genotypic resistance of cytomegalovirus to antivirals in hematopoietic stem cell transplant recipients from Portugal: A retrospective study

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• 作者：Ana Bela Campos^a ; ^d ; Joana Ribeiro^a ; ^b ; ^d ; Carlos Pinho Vaz^c ; Fernando Campilho^c ; Rosa Branca^c ; Antó ; nio Campos Jr.^c ; Inê ; s Baldaque^b ; Rui Medeiros^a ; ^b ; ^h ; David Boutolleau^e ; ^f ; ^g ; Hugo Sousa^a ; ^b ; ^{hugomls@gmail.com} ; ^{hugo.sousa@ipoporto.min-saude.pt}
• 关键词：Cytomegalovirus ; HCMV ; Resistance mutations ; UL97 ; UL54 ; Hematopoietic stem cell transplant
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：138
• 期：Complete
• 页码：86-92
• 全文大小：515 K
• 卷排序：138

文摘

We have analysed HCMV mutations in UL97 and UL54 in allogeneic HSCT patients. 5 patients had UL97 resistance mutations (C592G, A594V, L595W and C603W). 2 patients had UL54 mutations (P522S and L957F). We have reported several new unknown mutations and natural polymorphisms. We have first reported a case with the L957F UL54 mutation in clinical samples.