Novel signaling of dynorphin at κ-opioid receptor/bradykinin B2 receptor heterodimers

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• 作者：Bingyuan Ji^a ; ^b ; Haiqing Liu^c ; Rumin Zhang^b ; Yunlu Jiang^b ; Chunmei Wang^b ; Sheng Li^b ; Jing Chen^b ; ^d ; ^{Jing.Chen@warwick.ac.uk} ; Bo Bai^b ; ^{bobai@mail.jnmc.edu.cn}
• 关键词：AC ; adenylyl cyclase ; B1R ; bradykinin B1 receptor ; B2R ; bradykinin B2 receptor ; BK ; bradykinin ; BRET ; bioluminescence resonance energy transfer ; CFP ; cyan fluorescent protein ; CNS ; central nervous system ; CRE ; cAMP-response element ; CREB ; cAMP-response element-binding protein ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; DMEM ; Dulbecco's modified Eagle's medium ; DOR ; δ-opioid receptor ; Dyn A(1&ndash ; 13) ; dynorphin A (1&ndash ; 13) ; DYN ; dynorphin ; FRET ; fluorescence resonance energy transfer ; FSK ; f
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：31
• 期：Complete
• 页码：66-78
• 全文大小：1820 K
• 卷排序：31

文摘

KOR and B2R form heterodimers that function as a novel pharmacological entity. KOR/B2R heteromers mediate the Gαs/cAMP/CREB signaling pathway. Dyn A(1–13) enhances proliferation of HEK293-KOR/B2R and SH-SY5Y cells. We reveal the molecular mechanism underlying neuroprotection mediated by KOR/B2R heterodimers.