Mulberry leaf polyphenol extract improves obesity by inducing adipocyte apoptosis and inhibiting preadipocyte differentiation and hepatic lipogenesis
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- 作者：Yun-Ching Changa ; b ; 1 ; Mon-Yuan Yanga ; 1 ; Shu-Chun Chena ; Chau-Jong Wanga ; b ; wcj@csmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：MLE ; mulberry leaf extract ; MLPE ; mulberry leaf polyphenolic extract ; HFD ; high-fat diet ; HPLC ; high-performance liquid chromatography ; NAFLD ; non-alcoholic fatty liver disease ; FAS ; fatty acid synthase ; SREBPs ; sterol regulatory element binding proteins ; PPAR-γ ; peroxisome proliferator activated receptors-gamma ; A-FABP ; adipocyte-specific fatty acid binding protein ; FAS ; fatty acid synthase ; AMPK ; adenosine monophosphate-activated protein kinase ; ACC ; acetyl-Coenzyme A carboxylase ; HMGCR ; 3-hyd
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：21
- 期：Complete
- 页码：249-262
- 全文大小：3287 K
文摘
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Leaves from Morus alba L. are a potential source of bioactive compounds.
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Caffeic acid, hesperetin, quercetin and hydroxyflavin were identified in MLPE.
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Inhibiting adipocyte differentiation in 3T3-L1 cells resulted in reduced fat.
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MLE and MLPE exhibited significant inhibition of TG and TC pathway.
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MLE and MLPE have potential applications in diet-based antiobesity intervention.