Sterol regulatory element-binding proteins are transcriptional regulators of the thyroglobulin gene in thyroid cells
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- 作者：Gaiping Wen ; Klaus Eder ; Robert Ringseis ; Robert.ringseis@ernaehrung.uni-giessen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thyroid hormone synthesis ; Thyroglobulin ; SREBP ; Functional SRE
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1859
- 期：8
- 页码：994-1003
- 全文大小：996 K
文摘
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Expression of rat TG is reduced by inhibition of SREBP maturation indicating that the TG gene is regulated by SREBP
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Expression of rat TG is reduced by knockdown of SREBPs which indicates that the TG gene is regulated by SREBPs
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nSREBPs activate the TG promoter indicating that regulation is mediated at the transcriptional level
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activation of the TG promoter by nSREBPs is mediated by binding of both SREBP isoforms to an E-box SRE in the TG promoter