MicroRNA-23a regulates 3T3-L1 adipocyte differentiation
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- 作者：Linyuan Shena ; 1 ; Yi Zhangb ; 1 ; Jingjing Dua ; Li Chena ; Jia Luoa ; Xuewei Lia ; Mingzhou Lia ; Guoqing Tanga ; Shunhua Zhanga ; zhangsh1919@163.com" class="auth_mail" title="E-mail the corresponding author ; Li Zhua ; zhuli7508@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACS ; acyl-CoA synthetase ; C/EBPα ; CCAAT/enhancer-binding proteins ; DM ; differentiation media ; DMEM ; Dulbecco's modified Eagle's medium ; DGAT ; diacylglycerol acyltransferase ; ELOVL ; elongation-of-very-long-chain-fatty acids ; FBS ; fetal bovine serum ; FAS ; fatty acid synthase ; GSK ; glycogen synthase kinase ; LPL ; lipoprotein lipase ; miRNAs ; MicroRNAs ; PPARγ ; peroxisome proliferator activated receptor-γ coactivator ; SREBP-1 ; sterol regulatory element-binding protein-1 ; SCD-1 ; stearoyl-CoA desaturase-
- 刊名：Gene
- 出版年：2016
- 出版时间：10 January 2016
- 年：2016
- 卷：575
- 期：2
- 页码：761-764
- 全文大小：695 K
文摘
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The role of miRNA-23a in adipocyte differentiation were firstly investigated.
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miRNA-23a influences lipid accumulation and triglyceride content was observed.
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miRNA-23a changes lipogenic transcription, fatty acid synthesis and fatty acid transport.