Actions of 17尾-estradiol and testosterone in the mitochondria and their implications in aging

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• 作者：Andrea Vasconsuelo ; Lorena Milanesi ; Ricardo Bol
• 关键词：17尾-estradiol ; Testosterone ; Aging ; Mitochondria ; Androgen receptor ; Estrogen receptor
• 刊名：Ageing Research Reviews
• 出版年：September, 2013
• 年：2013
• 卷：12
• 期：4
• 页码：907-917
• 全文大小：1578 K

文摘

A decline in the mitochondrial functions and aging are two closely related processes. The presence of estrogen and androgen receptors and hormone-responsive elements in the mitochondria represents the starting point for the investigation of the effects of 17尾-estradiol and testosterone on the mitochondrial functions and their relationships with aging. Both steroids trigger a complex molecular mechanism that involves crosstalk between the mitochondria, nucleus, and plasma membrane, and the cytoskeleton plays a key role in these interactions. The result of this signaling is mitochondrial protection. Therefore, the molecular components of the pathways activated by the sexual steroids could represent targets for anti-aging therapies. In this review, we discuss previous studies that describe the estrogen- and testosterone-dependent actions on the mitochondrial processes implicated in aging.