Redox/pH dual stimuli-responsive degradable Salecan-g-SS-poly(IA-co-HEMA) hydrogel for release of doxorubicin
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- 作者：Xinyu Hua ; huxinyulhs@163.com" class="auth_mail" title="E-mail the corresponding author ; Yongmei Wanga ; Liangliang Zhanga ; Man Xua ; Wei Dongb ; Jianfa Zhangb
- 关键词：Salecan ; Hydrogel ; Redox/pH stimuli-responsive ; Degradation ; Controlled drug delivery
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：2 January 2017
- 年：2017
- 卷：155
- 期：Complete
- 页码：242-251
- 全文大小：3510 K
文摘
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Salecan-g-SS-PIH hydrogel presented an obviously pH-dependent DOX release behavior.
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DOX-loaded hydrogels showed dose dependent cytotoxicity toward A549 cell.
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Efficient cell killing was observed for DOX-loaded hydrogels.
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The hydrogel can totally degrade in the reductive environment.