Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle
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- 作者：Ling Yang1 ; 11 ; Danilo Licastro2 ; 11 ; Edda Cava3 ; 4 ; 11 ; Nicola Veronese3 ; 5 ; Francesco Spelta3 ; 6 ; Wanda Rizza3 ; 7 ; Beatrice Bertozzi3 ; Dennis T. Villareal3 ; 8 ; Gö ; khan S. Hotamisligil1 ; John O. Holloszy3 ; Luigi Fontana3 ; 9 ; 10 ; lfontana@dom.wustl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：calorie restriction ; cortisol ; aldosterone ; HSP70 ; autophagy
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 January 2016
- 年：2016
- 卷：14
- 期：3
- 页码：422-428
- 全文大小：1500 K
文摘
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Calorie restriction increases health-span and lifespan in model organisms
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Little is known about the metabolic and molecular effects of CR in humans
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CR inhibits inflammation in part by increasing serum cortisol concentration
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CR elevates expression of genes and proteins that enhance protein quality control