GB virus C/hepatitis G virus infection among patients with hepatocellular carcinoma

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• 作者：Tanaka ; Yasuhito ; Mizokami ; Masashi ; Kato ; Takanobu ; Matsumoto ; Yuko ; Ishihama ; Tetsuyoshi ; et. al.
• 关键词：GB virus C ; Hepatitis G virus ; Hepatocellular carcinoma ; NS3
• 刊名：Hepatology Research
• 出版年：1997
• 出版时间：August, 1997
• 年：1997
• 卷：8
• 期：1
• 页码：44-51
• 全文大小：406 K

文摘

To elucidate the prevalence and association of GB virus Clhepatitis G virus (GBV-C/HGV) infection among patients with hepatocellular carcinoma (HCC), GBV-C/HGV RNA was screened by the reverse transcription polymerase chain reaction using the specific primers derived from 5′-untranslated region and NS3 in sera from 60 HCC patients admitted in our hospital between 1993 and 1996. Of 60 patients, 12 (20 % ) showed positivity for one of HBV related viral markers such as HBsAg, anti-HBs, anti-HBc and HBV DNA, 24 (40 % ) for one of HCV markers such as anti-HCV and HCV RNA, 18 (30 % ) for both HBV and HCV markers, and six (10 % ) showed negativity for both HBV and HCV markers. GBV-C/HGV RNA was detected in five (8.3 % ). One patient (8.3 % ) was included in 12 HCC patients with HBV markers, one (4.2 % ) was in 24 with HCV markers alone, and two (11.1 % ) was in 18 with HBV and HCV markers, and one (16.7 % ) was in six without HBV and HCV markers. Only the history of blood transfusion was significantly different between the patients with and without GBV-C/HGV RNA. These results indicated that: (1) GBV-C/HGV infection is associated with only a small proportion of HCC; (2) blood transfusion is a major important route for GBV- C/HGV transmission; (3) laboratory findings and characteristics of HCC are not significantly different between HCC patients with and without GBV-C/HGV.