A comprehensive evaluation of the [2-14C](-)-epicatechin metabolome in rats
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- 作者：Gina Borges ; Justin J.J. van der Hooft1 ; Alan Crozier ; alan.crozier44@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MS ; mass spectrometry ; RC ; radiocounting ; SREM ; structurally-related epicatechin metabolite ; 5C-RFM ; ring fission metabolite with a 5-carbon side chain ; 3/1C-RFM ; hippuric acid and ring fission metabolites with a one or three carbon side chain
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：128-138
- 全文大小：1062 K
文摘
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Ingested [2-14C]-epicatechin is metabolized extensively by rats.
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19 radiolabeled metabolites and microbiota-derived catabolites were identified.
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78% of the ingested radioactivity was excreted in urine and 19% in feces.
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No oxidized metabolites of [2-14C]-epicatechin were detected.
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Epicatechin metabolism in rats is very different to that occurring in humans.