NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone
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- 作者：Ryan E. Tomlinson1 ; Zhi Li1 ; Qian Zhang1 ; Brian C. Goh1 ; Zhu Li1 ; Daniel L.J. Thorek2 ; 3 ; Labchan Rajbhandari4 ; Thomas M. Brushart1 ; Liliana Minichiello5 ; Fengquan Zhou1 ; Arun Venkatesan4 ; Thomas L. Clemens1 ; 6 ; 7 ; tclemen5@jhmi.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：sensory nerves ; endochondral bone ; nerve growth factor ; neurotrophic tyrosine kinase receptor type 1
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：16
- 期：10
- 页码：2723-2735
- 全文大小：6198 K
文摘
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TrkA sensory nerves extend from the DRG to sites of incipient bone formation
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Perichondrial osteochondral progenitors express NGF until early postnatal life
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Inhibiting NGF-TrkA signaling during embryogenesis impairs normal bone development
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NGF-TrkA signaling coordinates innervation, vascularization, and ossification