Palladium-catalyzed one-pot synthesis of benzo[b][1,6]naphthyridines via Sonogashira coupling and annulation reactions from 2-chloroquinoline-3-carbonitriles
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- 作者：Radhey M. Singh ; Ritush Kumar ; Neha Sharma ; Mrityunjaya Asthana
- 关键词：Palladium ; One-pot ; 2-Chloroquinoline-3-carbonitrile ; Intramolecular ; [1 ; 6]Naphthyridine
- 刊名：Tetrahedron
- 出版年：2013
- 出版时间：11 November, 2013
- 年：2013
- 卷：69
- 期：45
- 页码：9443-9450
- 全文大小：1434 K
文摘
Palladium-catalyzed one-pot synthesis of 1,3-disubstituted benzo[b][1,6]naphthyridines and [1,6]naphthyridines has been described from easily accessible precursors, 2-chloroquinoline-3-carbonitriles and 2-chloropyrido-3-carbonitrile via sequential additions of palladium-catalyst for Sonogashira-coupling and the following annulations in good to excellent yields. A plausible mechanism for annulation is discussed.