Interplay of multiple interaction forces: Binding of tyrosine kinase inhibitor nintedanib with human serum albumin
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- 作者：Parvez Alama ; 1 ; Ali S. Abdelhameedb ; 1 ; Ravi Kant Rajpootc ; Rizwan Hasan Khana ; rizwanhkhan@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; rizwanhkhan1@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：NIB ; Nintedanib ; HSA ; Human serum albumin
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：157
- 期：Complete
- 页码：70-76
- 全文大小：970 K
文摘
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Nintedanib leads to increase in alpha helical content in HSA.
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Nintedanib induced compaction in hydrodynamic radii of HSA.
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Nintedanib induced microenvironment change around tryptophan residue.
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Both hydrophobic as well as electrostatic interactions are involved between nintedanib and HSA.