Interaction of the recently approved anticancer drug nintedanib with human acute phase reactant α 1-acid glycoprotein
详细信息 查看全文
- 作者：Ali Saber Abdelhameeda ; 1 ; Mohammad Rehan Ajmalb ; 1 ; Kalaiarasan Ponnusamyc ; Naidu Subbaraoc ; Rizwan Hasan Khanb ; rizwanhkhan@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; rizwanhkhan1@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alpha-1 acid glycoprotein ; Fluorescence spectroscopy ; Anticancer drug binding ; Dynamic molecular docking ; Circular dichroism
- 刊名：Journal of Molecular Structure
- 出版年：2016
- 出版时间：5 July 2016
- 年：2016
- 卷：1115
- 期：Complete
- 页码：171-179
- 全文大小：1710 K
文摘
- •
Binding process nintedanib to human Alpha-1 acid glycoprotein under simulated physiological conditions were studied.
- •
Alpha-1 acid glycoprotein (AAG) is a major acute phase reactant, a major glycoprotein of the human plasma.
- •
Secondary and tertiary structure alterations in the protein were observed and there is reduction in the hydrodynamic radii of the protein.
- •
Dynamic molecular docking was performed.
- •
Docking study show that nintidanib and two commonly used anticancer compounds clofarabine and methotrexate revealed overlapping regions.