RKIP suppresses the proliferation and metastasis of breast cancer cell lines through up-regulation of miR-185 targeting HMGA2
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- 作者：Qiongyan Zoua ; 1 ; Haijun Wub ; 1 ; Fenfen Fuc ; Wenjun Yia ; wenjun_yi_xiangya@163.com" class="auth_mail" title="E-mail the corresponding author ; Lei Peia ; Meirong Zhoua
- 关键词：RKIP ; MIR-185 ; HMGA2 ; Breast cancer ; Growth ; Invasion
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：610
- 期：Complete
- 页码：25-32
- 全文大小：2440 K
文摘
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RKIP positively regulates miR-185 expression in breast tissues and cell lines.
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RKIP/miR-185 axis regulates breast cancer cells proliferation and invasion.
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HMGA2 mRNA inversely correlated to miR-185 in breast tissues and cell lines.
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miR-185 inhibits HMGA2 expression by binding to its 3′UTR.
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miR-185 inhibits breast cancer cell growth through HMGA2.