Raf kinase inhibitor protein mediated signaling inhibits invasion and metastasis of hepatocellular carcinoma
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- 作者：Xiaohui Wua ; 1 ; Yongjiang Yangb ; 1 ; Zhuo Xua ; Jiankun Lia ; Baoming Yanga ; Ningning Fenga ; Yueshan Zhanga ; Shunxiang Wanga ; gdwangsx@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatocellular carcinoma ; RKIP ; Signaling transduction ; Invasion ; Metastasis
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1860
- 期：2
- 页码：384-391
- 全文大小：1149 K
文摘
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We investigated RKIP in cellular proliferation, migration, invasion and apoptosis.
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We found decreased RKIP expression in HCC tissues.
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We found that RKIP functioned to inhibit HCC cell motility and invasiveness.
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Function of RKIP was mediated through MAPK and NF-κB signaling pathways.