GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity
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- 作者：Allison Doyle Brackley1 ; Ruben Gomez2 ; Armen N. Akopian3 ; Michael A. Henry3 ; Nathaniel A. Jeske1 ; 2 ; 4 ; 5 ; jeske@uthscsa.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：16
- 期：10
- 页码：2686-2698
- 全文大小：3662 K
文摘
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GRK2 naively associates with peripheral DOR, maintaining incompetent state
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GRK2 interaction, not kinase activity, underlies peripheral DOR incompetence
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Knock down of GRK2 increases peripheral DOR-mediated analgesia in vivo
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BK induces PKC-dependent RKIP sequestration of GRK2, increasing DOR competence