Understanding the role of dynamics in the iron sulfur cluster molecular machine

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• 作者：Danilo di Maio^a ; ^b ; Balasubramanian Chandramouli^a ; ^b ; Robert Yan^c ; Giuseppe Brancato^a ; ^b ; ^{giuseppe.brancato@sns.it} ; Annalisa Pastore^c ; ^d ; ^{annalisa.pastore@crick.ac.uk}
• 关键词：NMR ; nuclear magnetic resonance ; MD ; molecular dynamics ; PCA ; principal component analysis ; ED ; essential dynamics ; RMSD ; root-mean square deviation ; RMSF ; root-mean-square fluctuation
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3154-3163
• 全文大小：2455 K
• 卷排序：1861

文摘

IscU protomers show a pivotal motion around the interface with IscS, in complex. Both IscS catalytic loop and IscU motion seem correlated with FeS cluster assembly. Shuttling of the IscS catalytic loop is accompanied by a structural transition. CyaY inhibits cluster formation by hampering the dynamics of the IscS-IscU complex.